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In euthyroid patients, doses within the range of daily hormonal requirements are ineffective for weight reduction. Thyroid hormones, including TIROSINT, either alone or with other therapeutic agents, should not be used for the treatment of obesity or for weight loss. NOT FOR TREATMENT OF OBESITY OR FOR WEIGHT LOSS IMPORTANT SAFETY INFORMATION for TIROSINT (levothyroxine sodium) CAPSULES EMPATHY: A new tool for identifying the most suitable thyroxine formulation in hypothyroid patients. Thyroxin softgel capsule in patients with gastric-related T4 malabsorption. Based on RelayHealth eVoucherRx™ Network pharmacy paid claims from April 2018–March 2019.Lugano, Switzerland: Institut Biochimique SA (IBSA) 2018. Herb and supplement use in the US adult population. When bioequivalence in healthy volunteers may not translate to bioequivalence in patients: differential effects of increased gastric pH on the pharmacokinetics of levothyroxine capsules and tablets. Seng Yue S, Benvenga S, Scarsi C, Loprete L, Ducharme MP.A comparative pH-dissolution profile study of selected commercial levothyroxine products using inductively coupled plasma mass spectrometry. Data on file, Institut Biochimique SA (IBSA).Comorbidities, concomitant medications, and diet as factors affecting levothyroxine therapy results of the CONTROL Surveillance Project. McMillan M, Rotenberg KS, Vora K, et al.The influence of lactose intolerance and other gastro-intestinal tract disorders on L-thyroxine absorption. Ruchala M, Szczepanek-Parulska E, Zybek A.Retrospective study of patients switched from tablet formulations to a gel cap formulation of levothyroxine: results of the CONTROL Switch Study. Ernst FR, Sandulli W, Elmor R, Welstead J, Sterman AB, Lavan MK.
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Lugano, Switzerand: Institut Biochimique SA (IBSA) 2018. Clinical Practice Guidelines for Hypothyroidism in Adults: Cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. ATA/AACE Taskforce on Hypothyroidism in Adults.Hypothyroidism: A Booklet for Patients and Their Families. Perhaps it’s time to try Tirosint?Ĭommonly used medicines and dietary supplements that can affect levothyroxine therapy 5 If you and your physician determine that you are experiencing tolerability or malabsorption problems that stem from your current thyroid medication, it may be the result of taking GI medication that can interfere with your treatment. Make sure to tell your doctor if you have any of the above GI conditions or if you take medications like PPIs. Tirosint was shown to be less affected by the presence of a PPI. A recent study has shown that taking a PPI can have a significant effect on the absorption of levothyroxine tablets. 5 Brand name PPI medications include Prilosec, Protonix and Nexium*. Many patients with GI conditions take a medication called a protein pump inhibitor (PPI). Under laboratory conditions, the effectiveness of Tirosint has been proven to be unaffected by changes in gastric acid level, unlike levothyroxine tablets. 4 Certain conditions or their treatments can alter the acid level in your stomach, which may impact how well you are able to absorb levothyroxine from a tablet. Some conditions, such as celiac disease or lactose intolerance, may be aggravated by the excipients commonly found in levothyroxine tablets. GI conditions and the medications used to treat them can affect the way your body dissolves and absorbs a traditional levothyroxine tablet. Confectioners’ sugar (contains cornstarch).Here is a partial list of excipients sometimes used to manufacture thyroid medications: 8 8 Tirosint gel caps are produced in a dedicated facility, where no other products are made, eliminating the risk of cross contamination from ingredients that may be used to make other medications. 6įor people with food allergies and ingredient sensitivities, Tirosint capsules can offer effective relief of hypothyroidism without wheat starch (gluten), lactose, food dyes, and sugars used to make traditional levothyroxine tablets-Tirosint gel caps contain only 4 simple ingredients. 5 In a recent survey of nearly 1,000 patients taking levothyroxine to treat their hypothyroidism, 15% of respondents reported allergies to the excipients commonly found in levothyroxine tablets. For people with serious food allergies or restrictions, exposure to even small quantities of certain ingredients may cause a serious reaction. Excipients (inactive ingredients) in levothyroxine tabletsĮveryone is paying closer attention to the ingredients found in the foods we consume these days, so it only makes sense to do the same with medication.